Endocrine Abstracts

Introduction: White adipose tissue (WAT) and brown adipose tissue (BAT) are key regulators of systemic metabolic function. Bone marrow adipose tissue (BMAT) accounts for 10% of total adipose mass in healthy humans and therefore can be considered a third major adipose subtype. However, it is unclear if BMAT contributes to systemic energy homeostasis.Objectives: Assess [18F]-Fluorodeoxyglucose (FDG) uptake into bone and the marrow cavity (MC) fo...

Introduction: The long-term mountain cycling effects on cognitive development for better performance, are still not fully elucidated. Notwithstanding, this type of exercise may induce a link with energy metabolism and sympathetic nervous system. We previously observed that a mountain cycling ultramarathon, induced a comodulatory influence of genetic- and exercise-associated factors on inflammatory and haemoglobin catabolic marker haptoglobin. We hypothesised that inflammatory ...

The use of immune checkpoint inhibitors (ICPI) for treatment of different advanced cancers has opened a new therapeutic window. Thyroid dysfunction is an often side effect described for these drugs.Objectives: To describe the thyroid alterations found in oncologic patients undergoing treatment with ICPI.Materials and methods: A descriptive, retrospective study of oncologic patients receiving treatment with ICPI referred to the Endo...

Introduction: The interaction between bone and energy metabolism may be enhanced in high demanding physical activities. We hypothesize that genetic background may modulate the exercise-associated bone and energy responses of athletes participating of a mountain cycling ultramarathon.Methods: Fifty-five non-professional athletes (mean age 44.8±7.1 years) participating in a 9-day mountain cycling ultramarathon (TransPortugal) were evaluated. Before an...

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...

Introduction: Maternally inherited diabetes and deafness (MIDD), is a rare entity. Most commonly, it is related to a point mutation in the mitochondrial DNA (mtDNA) at position 3243 (m.3243A>G) encoding the gene for tRNA. A high index of suspicion is required for the diagnosis due to a wide heterogeneity in its clinical presentation which reflects different levels of mutated mtDNA among mitochondria in a given tissue (heteroplasmy). Thyroid cancer risk has never been speci...

Introduction: Cryptorchidism is the most common abnormality of male sexual development. Approximately 5% of cases of cryptorchidism are associated with vanishing testes syndrome. This rare condition occurs when an initially normal testicle that existed in fetal life subsequently atrophies. Affected patients usually have normal male external genitalia and hypergonadotropic hypogonadism. This disease is usually diagnosed in early childhood allowing for normal sexual development ...

Thyroid uptake scan is a widely used thyroid investigation that provides valuable information regarding the structure and function of the gland and helps in differentiating some of the common thyroid pathologies. We present a multicentre audit of thyroid uptake scans done for non-malignant thyroid pathologies and try to analyse the usefulness of this investigation in different situations.MethodsThis audit includes thyroid uptake sc...

Background: The incidence of thyroid cancer (TC) has been increasing in recent years while mortality has remained stable. The cause of this increase is unclear, although several hypotheses have been proposed. While the increased incidence may only be apparent due to increased testing, there is data that suggest that there may be a real increase in incidence related to different risk factors. The aim of this meta-analysis was to determine the current incidence of TC in Europe.<...